Biorepositories for NCI-Sponsored Cancer Clinical Trials

CGB Organization

The CGB is composed of biorepositories of well-annotated specimens, which are integral components of the nine* NCI-sponsored Clinical Trials Cooperative Groups listed below as well as the NCIC-CTG. Membership in the Cooperative Groups is not required for access to the CGB biospecimens.

*NCIC-Clinical Trials Group (NCIC-CTG) is not supported by the United States NCI but is part of the CGB.

Most CGB receive and store solid tumor biospecimens. Collectively, biorepositories house all organ types, including brain, breast, gastrointestinal, genitourinary, gynecological, head and neck, melanoma-skin, peripheral nervous system, liver, lung, soft tissue sarcoma, and thyroid gland as represented in trials conducted by their respective Cooperative Groups.

The solid tumor banks receive and store formalin-fixed, paraffin-embedded (FFPE) blocks and histological slides from diagnostic biopsies and surgical resections from cancer patients. Seven banks also collect fresh frozen specimens in at least some of their trials. Several Groups also have hematological malignancy banks, including leukemia, lymphoma, and multiple myeloma as well as serum and plasma banks; several collect and store uninvolved control tissues and/or germ line DNA samples. Please refer to the individual banks for additional information regarding their specific types of stored specimens.

From 2000-2007, the CGB collected more than 800,000 solid tumor specimens, more than 140,000 serum specimens, and nearly 50,000 leukemia specimens.